Topic signal
Research-focused AI signal from labs, technical talks, and scientific breakthroughs.
(0:00) Bestie intros: Happy Fourth of July! (0:21) Palantir-Nvidia open source deal, Alex Karp's CNBC "Crashout" (33:52) Update on the AI jobs debate (50:24) Anthropic's Fable 5 a…
Emily Chang goes inside the world of supermodel-turned-entrepreneur Karlie Kloss to explore how she’s trying to revive magazine publishing. Watch more of The Circuit with Emily Ch…
Yoko Li speaks with Luma's Head of Applied Research Matt Tancik and Phota Labs cofounder and CTO Zach Xia about how AI is changing creativity, photography, and the tools people us…
Dylan Patel, founder of SemiAnalysis, argues the biggest gains in AI don't come from faster chips, they come from software-hardware co-design. Optimizing the model, the kernels, a…
📌 Head to https://granola.ai/marina and enter the code MARINA for 3 months off. Richard Socher is the fourth most-cited researcher in the history of natural language processing —…
The structure of the modern AI industry has been shaped largely by scaling laws. Large, general-purpose models have conclusively outper…
Matt Bornstein speaks with Mirendil cofounders Behnam Neyshabur and Harsh Mehta about their vision for building self-accelerating AI. After leading research efforts at Google and…
Following a string of departures among its top AI leaders, @googledeepmind CEO Demis Hassabis dismissed the notion that ...
The conversation of the moment is focused on one topic: AI agents. Unlike traditional language models that simply respond to a prompt, autonomous agents can execute multi-step pla…
Fiona Fung leads the teams behind Claude Code and Cowork at Anthropic (overseeing Boris Cherny and the entire engineering and PM team). Before Anthropic, she spent 11 years at Mic…
(0:00) Bestie intros! (2:41) The New Oligarchs, America's incoming politburo, and learned helplessness (14:18) SpaceX's record breaking IPO, $60B Cursor acquisition, and trilliona…
Emily Chang sits down with Anthropic CEO Dario Amodei in a wide-ranging interview discussing his San Francisco roots, the race against OpenAI, the Pentagon standoff and AI’s endga…
The race to build superintelligence is producing models that keep getting better at objective problems, but not at behaving like actual people. Joon Sung Park, founder and CEO of…
Yoko Li and Justine Moore speak with Ideogram founder and CEO Mohammad Norouzi about image generation models, design workflows, and the evolving relationship between AI and creati…
(0:00) Besties are back! (0:19) Anthropic gets massive backlash over secret Fable nerfing and privacy concerns (29:16) The AI regulatory capture trap, pragmatic safety solutions (…
It's hard to keep up with the latest AI research. That's why we started YC Paper Club — a small group of researchers, engineers, and founders who meet every two weeks at our Mount…
The entire startup ecosystem is racing to build agent harnesses. Logan Kilpatrick, who leads Google AI Studio and the Gemini API, argues that scramble has a roughly 12-month shelf…
Emily Chang meets Anthropic co-founders Dario and Daniela Amodei for a rare, in-depth discussion of the startup's origin story, its battles with the Pentagon and how the company s…
Daniela Amodei, President & Co-Founder at Anthropic discusses the latest in model development, its commercialization strategy ...
Today, we’re excited to be publishing an excerpt from Dr. Fei-Fei Li ’s recent blogpost on World Models. You can read more…
(0:00) OpenAI CFO Sarah Friar joins the show! (0:31) How OpenAI thinks about its IPO timeline (3:31) OpenAI, Anthropic, Google: The AI arms race (7:43) Navigating the compute crun…
(0:00) Bill Gurley joins the show! (6:00) Making yourself valuable in the age of AI, first class of "AI Natives" (17:37) Reacting to Pope Leo's AI encyclical: Who guards the guard…
Even if you’re a current PhD student, it's hard to keep up with the latest AI research. That's why we started YC Paper Club, a small group of researchers, engineers, and founders…
Cursor's Federico Cassano and Fireworks' Dmytro Dzhulgakov explain how they collaborated to build Composer as a specialized foundation model. The core insight: models have finite…
(0:00) Gavin Baker joins the show! (0:30) Andrej Karpathy joins Anthropic; hypergrowth and profitability (12:42) Why Americans have turned on AI, anti-human perception (27:22) Tru…
We are at an incredibly exciting and consequential moment for AI. Join Google DeepMind co-founder and CEO Demis Hassabis ...
Last Saturday morning, three teenagers stole a handgun from Central Texas Gunworks in Austin. In the next twenty-eight hours, they shot…
AnswerThis builds AI agents for evidence-based scientific workflows and has scaled past $2 million in ARR with just two full-time employees — largely because they built an interna…
In an era of information overload, the search for transformative scientific ideas has become a significant bottleneck for progress. Every great scientific breakthrough begins with…
Globally recognized as a silent pandemic, antimicrobial resistance continues to rise as bacteria outpace the development of new antibiotics. When patients stop responding to stand…
In Uganda, the incidence of early-onset breast cancer is growing at an alarming rate. Dr. Daudi Jjingo and his team at Makerere University are working to identify genetic targets…
Tropical storms and hurricanes are notoriously volatile, changing structure and intensity in a matter of hours. This unpredictability makes them some of the most challenging weath…
David Ulevitch speaks with Col. Jeffrey Glover and Rahul Sidhu about how AI, drones, and sensor networks are reshaping public safety and what it takes to bring new technology into…
今天是我们的系列节目《Freda的投资札记》第2集。 可能有听众是第一次听我们的节目，那还是先介绍一下——Freda Duan在湾区做投资，是Altimeter Capital的合伙人。Altimeter是一个硅谷科技基金，横跨一二级。在一级市场投资案例有OpenAI、Anthropic、字节跳动等，在二级市场投资案例有英伟达、存储芯片、Snowflake…
Our views on the AI competition between the US and China.
Most music platforms assume you're a listener. On Suno, 90% of daily users make something. Founder and CEO Mikey Shulman explains why that flips the model: the act of creating IS…
The mouse pointer 🖱️ has been a constant companion on computer screens, across every website, document and workflow. Despite how technologies have changed, the pointer has barely…
Yao Shunyu walks in wearing a pair of amber-tinted glasses that shift color with the light. There are two Yao Shunyus in Silicon Valley's AI circles—both graduated from Tsinghua i…
姚顺宇戴了一副茶色眼镜走过来，这副眼镜会随光线变化而改变颜色。 硅谷AI业界有两位Yao Shunyu，他们曾是清华同一届毕业生，这让姚顺雨与姚顺宇时常成为话题人物。 前一位姚顺雨2025年从OpenAI跳槽到腾讯，他去年来过我们节目（第115集 (https://www.xiaoyuzhoufm.com/episode/68c29ca12c82c9dcc…
Eric Ries is the author of The Lean Startup, a book that reshaped how a generation of founders think about building companies. His new book, Incorruptible, explains how successful…
Alignment
At AI Ascent 2026, Ben and Asher Spector, brothers and co-founders of the AI lab Flapping Airplanes, argue that the future of AI belongs to whoever can build models that need a lo…
Turning Claude's thoughts into text
Updating Petri to version 3.0 and donating it to Meridian Labs
Policy
Boris Cherny, creator of Claude Code at Anthropic, joins Sequoia partner Lauren Reeder at AI Ascent 2026 to talk about where coding goes from here. He explains why he hasn't writt…
Jim Fan, who leads the embodied autonomous research group at Nvidia, returns to AI Ascent to argue that robotics is entering its end game — and that the playbook is already writte…
Learn how Stripe is making products legible to agents, building deterministic tools so agent actions are predictable and auditable, and designing auth and safety patterns that kee…